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Indications and usage of theophylline

Theo-24 Extended-release capsules meet Drug Release Test 6 as published in the current USP monograph for Theophylline Extended-release Capsules. Theophylline at least twofold by absorption of Theophylline secreted into gastrointestinal fluids. Charcoal must be retained in, and pass through, the gastrointestinal tract to be effective; emesis should therefore be controlled by administration of appropriate antiemetics. Alternatively, the charcoal can be administered continuously through a nasogastric tube in conjunction with appropriate antiemetics. A single dose of sorbitol may be administered with the activated charcoal to promote stooling to facilitate clearance of the adsorbed Theophylline from the gastrointestinal tract. Sorbitol alone does not enhance clearance of Theophylline and should be dosed with caution to prevent excessive stooling which can result in severe fluid and electrolyte imbalances. Commercially available fixed combinations of liquid charcoal and sorbitol should be avoided in young children and after the first dose in adolescents and adults since they do not allow for individualization of charcoal and sorbitol dosing. In patients with intractable vomiting, extracorporeal methods of Theophylline removal should be instituted see OVERDOSAGE, Extracorporeal Removal. tofranil

Theophylline overdose

Marchlinski FE, Miller JM "Atrial arrhythmias exacerbated by theophylline: response to verapamil and evidence for triggered activity in man. Ask your pharmacist about using those products safely. Administer multiple-dose oral activated charcoal and measures to control emesis. Skip next dose and decrease subsequent doses at least 25% even if no adverse effects are present. Only a few patients had a history of previous hypersensitivity reactions. Serious hypersensitivity reactions have also been reported following treatment with enoxacin. If an to enoxacin occurs, discontinue the drug.

Hurst 2004; elevate extremity

CYP1A2 Inhibitors Strong: May decrease the metabolism of CYP1A2 Substrates. Theophylline can cause side effects that may impair your thinking or reactions. Theophylline is rapidly and completely absorbed after oral administration in solution or immediate-release solid oral dosage form. Theophylline does not undergo any appreciable pre-systemic elimination, distributes freely into fat-free tissues and is extensively metabolized in the liver. Patients who metabolize theophylline at a normal or slow rate are reasonable candidates for once-daily dosing with Theo-24.

Does theophylline interact with other medications

It shows up less on darker skin. So if you have light skin, a self-tanner may make the bumps and dimples harder to spot. There are other ways to get rid of cellulite. Some work better than others. FDA pregnancy category C. It is not known whether theophylline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. SDwhere actual range not reported. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions.



Theophylline has been reported

Central nervous system: Theophylline-induced nonconvulsive status epilepticus has been reported rarely and should be considered in patients who develop CNS abnormalities. Sintek C, Hendeles L, Weinberger M. Inhibition of theophylline absorption by activated charcoal. If you miss a dose, skip the missed dose. Take your next dose at the regular time. Discuss the risks and benefits with your doctor. Changes in your body during the last may affect the amount of this drug in your blood. Your doctor should carefully monitor the amount of drug in your blood, as well as any side effects, so that your dose may be changed if needed. Quinolone-class adverse reactions: Although not reported in completed clinical studies with enoxacin, a variety of adverse events have been reported with other quinolones. Uniphyl theophylline anhydrous tablet Tablets on a mg-for-mg basis. Deferasirox: May increase the serum concentration of Theophylline. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products.



List of theophylline side effects

Those patients who require increased daily doses are more likely to experience relatively wide peak-trough differences and may be candidates for twice-a-day dosing with Theo-24. The use of theophyllines is associated with an increase in heart rate which may progress to supraventricular tachycardia or ventricular arrhythmia at high serum drug concentrations. Appearance of cardiac adverse effects is generally an indication of theophylline toxicity, although patients with a history of tachyarrhythmias may be more susceptible to the chronotropic effect of these drugs. Therapy with theophyllines should be administered cautiously in such patients. Caution is also advised in patients with hypertension, hyperthyroidism, angina pectoris, or recent myocardial infarction, since high dosages of the drugs are associated with positive inotropic as well as chronotropic effects. Clinical monitoring of serum drug concentrations is recommended to prevent toxicity. Convulsions and electroencephalograms have been reported in some patients receiving enoxacin. Increased pressure, and toxic psychoses have been reported in patients receiving drugs in this class. Chazan R, Karwat K, Tyminska K, Tadeusiak W, Droszcz W "Cardiac arrhythmias as a result of intravenous infusions of theophylline in patients with airway obstruction. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Not all side effects for aminophylline may be reported. You should always consult a doctor or healthcare professional for medical advice. clozapine



May lower theophylline seizure threshold

Zileuton: May increase the serum concentration of Aminophylline. Management: Reduce aminophylline dose by 50% upon initiation of zileuton therapy. If aminophylline is added to existing zileuton therapy, use a lower starting dose. Monitor for increased theophylline serum concentrations and effects. Propafenone: May increase the serum concentration of Theophylline Derivatives. If the patient is vomiting, the charcoal should be administered through a nasogastric tube or after administration of an antiemetic. Phenothiazine antiemetics such as prochlorperazine or perphenazine should be avoided since they can lower the seizure threshold and frequently cause dystonic reactions. A single dose of sorbitol may be used to promote stooling to facilitate removal of theophylline bound to charcoal from the gastrointestinal tract. Sorbitol, however, should be dosed with caution since it is a potent purgative which can cause profound fluid and electrolyte abnormalities, particularly after multiple doses. Commercially available fixed combinations of liquid charcoal and sorbitol should be avoided in young children and after the first dose in adolescents and adults since they do not allow for individualization of charcoal and sorbitol dosing. Ipecac syrup should be avoided in theophylline overdoses. Although ipecac induces emesis, it does not reduce the absorption of theophylline unless administered within 5 minutes of ingestion and even then is less effective than oral activated charcoal. Moreover, ipecac induced emesis may persist for several hours after a single dose and significantly decrease the retention and the effectiveness of oral activated charcoal. What happens if I miss a dose Uniphyl? Gastrointestinal side effects have included anorexia, nausea, vomiting, and abdominal pain. Theophylline may also cause locally-mediated gastrointestinal upset. Some of the side effects that can occur with aminophylline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. The respective AUC 0-inf. Theophylline concentration compared to patients without the underlying disease. The patient should be instructed to contact their healthcare professional if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another healthcare professional adds a new medication or discontinues a previously prescribed medication. Patients should be informed that theophylline interacts with a wide variety of drugs see Table II. The dietary supplement St. John's Wort Hypericum perforatum should not be taken at the same time as theophylline, since it may result in decreased theophylline levels. If patients are already taking St. John's Wort and theophylline together, they should consult their healthcare professional before stopping the St. John's Wort, since their theophylline concentrations may rise when this is done, resulting in toxicity. Patients should be instructed to inform all healthcare professionals involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their healthcare professional. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose. What should I discuss with my healthcare provider before taking theophylline Uniphyl? marex.info venlafaxine



Mayo Clinic: “Cellulite Treatment

Caffeine and 3-methylxanthine are the only theophylline metabolites with pharmacologic activity. Theophylline is somewhat removed with hemodialysis. A 50% supplemental dose or administering the dose post dialysis is recommended. A supplemental dose is not needed with peritoneal dialysis. Theophylline, even if another cause is suspected. The patient should be instructed to contact their healthcare professional if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another healthcare professional adds a new medication or discontinues a previously prescribed medication. Patients should be informed that Theophylline interacts with a wide variety of drugs see Table II. Due to the immaturity of theophylline metabolic pathways in infants under the age of one year, particular attention to dosage selection and frequent monitoring of serum theophylline concentrations are required when theophylline is prescribed to pediatric patients in this age group. Drug-Drug Interactions: Theophylline interacts with a wide variety of drugs. DexPak are often used during asthma flares to provide prompt relief for patients. Although very effective, these medications have many side effects and are only used when absolutely necessary. Some patients with severe asthma, however, may require oral steroids frequently or even on a daily basis. Mexiletine: May decrease the metabolism of Theophylline Derivatives. dutasteride price germany



What happens if I miss a dose?

The pharmacokinetics of Theophylline vary widely among similar patients and cannot be predicted by age, sex, body weight or other demographic characteristics. In addition, certain concurrent illnesses and alterations in normal physiology see Table I and co-administration of other drugs see Table II can significantly alter the pharmacokinetic characteristics of Theophylline. Within-subject variability in metabolism has also been reported in some studies, especially in acutely ill patients. The clinical importance of these changes should be weighed against the potential therapeutic benefit of theophylline in individual patients. Enoxacin did not induce point mutations in cells or conversion in cells, with or without activation. Enoxacin did not induce sister chromatid exchanges or structural chromosomal aberrations in mammalian cells in vitro, with or without metabolic activation. In addition, enoxacin did not induce chromosomal aberrations in mice. Do not stop taking any medications without consulting your healthcare provider. While the mechanisms of action of theophylline are not known with certainty, studies in animals suggest that bronchodilatation is mediated by the inhibition of two isozymes of phosphodiesterase PDE III and, to a lesser extent, PDE IV while non-bronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. AtoMOXetine may enhance the tachycardic effect of Sympathomimetics. It could give results for 2 to 6 months, but more research about how well it works and how long results may last is needed. What are the specific controller medications for asthma? Other quinolones also produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. Taniguchi A, Ohe T, Shimorura K "Theophylline-induced ventricular tachycardia in a patient with chronic lung disease: sensitivity to verapamil. If the patient's symptoms are well controlled, there are no apparent adverse effects, and no intervening factors that might alter dosage requirements see and serum theophylline concentrations should be monitored at 6 month intervals for rapidly growing children and at yearly intervals for all others. Note: Doses should be adjusted to maintain the peak steady state serum concentrations. The time to reach steady state will vary based on age and the presence of risk factors which may affect theophylline clearance. Shannon M "Predictors of major toxicity after theophylline overdose. The drugs listed in Table II have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of Table II assumes that the interacting drug is being added to a steady-state theophylline regimen. hydrea pharmacy price



What conditions does theophylline treat

Jain R, Tholl DA. Activated charcoal for theophylline toxicity in a premature infant on the second day of life. Long-acting bronchodilators can be added to inhaled corticosteroids. These should never be used alone for the treatment of asthma. Salmeterol and formoterol are in this class. Because theophylline interacts with many different medicines, tell your doctor about all medicines you are taking. Your doctor also will check the level of theophylline in your blood regularly to make sure it is not too high. Do not give this medication to anyone under 18 years old without medical advice. Theophylline clearance is decreased by 50% or more in patients with CHF. The extent of reduction in theophylline clearance in patients with CHF appears to be directly correlated to the severity of the cardiac disease. Since theophylline clearance is independent of liver blood flow, the reduction in clearance appears to be due to impaired hepatocyte function rather than reduced perfusion. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Thus, blood samples taken 4 to 8 hours post-dosing should reference the peak serum level for most patients. Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. Iopamidol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iopamidol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants.



Dosage: Should be individualized

Take this by as directed by your doctor, usually once or twice daily. Since different manufacturers have different ways to take this medication, ask your doctor or about the best times to take your brand of theophylline and if you should take the drug with or without food. Minton NA, Henry JA. Prevention of drug absorption in simulated theophylline overdose. Higher doses of Theophylline may be required to achieve desired effect. Table III. Drugs that have been documented not to interact with theophylline or drugs that produce no clinically significant interaction with theophylline. Case reports of theophylline overdose in humans and animal studies suggest that phenytoin is ineffective in terminating theophylline-induced seizures. The doses of benzodiazepines and phenobarbital required to terminate theophylline-induced seizures are close to the doses that may cause severe respiratory depression or respiratory arrest; the clinician should therefore be prepared to provide assisted ventilation. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Barbiturate-induced coma or administration of general anesthesia may be required to terminate repetitive seizures or status epilepticus. General anesthesia should be used with caution in patients with theophylline overdose because fluorinated volatile anesthetics may sensitize the myocardium to endogenous catecholamines released by theophylline. Enflurane appears less likely to be associated with this effect than halothane and may, therefore, be safer. Neuromuscular blocking agents alone should not be used to terminate seizures since they abolish the musculoskeletal manifestations without terminating seizure activity in the brain. International Academy of Cosmetic Dermatology: “Cellulite. Barry M, Feely J. Allopurinol influences aminophenazone elimination. In contrast, approximately 50% of the administered Theophylline dose is excreted unchanged in the urine in neonates. Macrolide Antibiotics: May decrease the metabolism of Theophylline Derivatives. Exceptions: Azithromycin Systemic; Fidaxomicin; Roxithromycin; Spiramycin; Telithromycin. Alcohol Ethyl: May increase the serum concentration of Theophylline. Lift weights at least 2 days a week. Focus on your legs, hips, and backside. Strong, defined muscles under a thinner fat layer will make your skin smoother and less puckered. For various North American patient populations from literature reports. Different rates of elimination and consequent dosage requirements have been observed among other peoples. Clearance represents the volume of blood completely cleared of theophylline by the liver in one minute. noroxin online rx pharmacy



How to take theophylline

Dosage adjustment based on serum theophylline concentrations: Note: Recheck serum theophylline concentration 24 hours after dosage adjustment. Theophylline clearance is altered by another drug resulting in increased or decreased serum Theophylline concentrations. Theophylline only rarely alters the pharmacokinetics of other drugs. If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Non-steroidal anti-inflammatory agents: Seizures have been reported in patients taking enoxacin concomitantly with the fenbufen. Animal studies also suggest an increased potential for seizures when these two drugs are given concomitantly. Fenbufen is not approved in the United States at this time. If you've been experiencing symptoms like those listed above, make an appointment with your doctor. Olodaterol. Theophylline Derivatives may enhance the hypokalemic effect of Olodaterol. LDL ratio, and urinary free cortisol excretion may be increased by theophylline. Theophylline may decrease triiodothyronine. The mechanism of theophylline-induced seizures has not been determined. Seizures are generally focal with secondary generalization. Permanent neurologic deficits have been reported and morbidity may be high, especially in the elderly, patients with severe underlying disease, and patients with prolonged, uncontrolled seizure activity. The onset of seizures is not always preceded by less severe symptoms of theophylline toxicity. Patients with an abnormal neurologic history, including a history of seizures, cerebral infarct, or head trauma, may be predisposed to seizure activity. If theophylline is used in these types of patients, serum concentrations should be monitored closely and maintained in the low, therapeutic range. ZYFLO is taken four times a day with or without food. Theophylline concentration when afebrile may be at greater risk of toxic effects from decreased clearance during sustained fever. Theophylline has been reported. Decreases Theophylline clearance by inhibiting cytochrome P450 1A2. Phenytoin: May decrease the serum concentration of Theophylline Derivatives. Theophylline Derivatives may decrease the serum concentration of Phenytoin. Management: Seek alternatives when possible. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Iomeprol. Specifically, the risk for seizures may be increased. Management: Discontinue agents that may lower the seizure threshold 48 hours prior to intrathecal use of iomeprol. Wait at least 24 hours after the procedure to resume such agents. In nonelective procedures, consider use of prophylactic anticonvulsants. aceon get quit program



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III are current as of February 9, 1995


Theophylline uses

Children 12-15 years and adults 16-60 years without risk factors for impaired clearance. General: The chronicity and pattern of Theophylline overdosage significantly influences clinical manifestations of toxicity, management and outcome. Theophylline concentrations should be monitored at 6 month intervals for rapidly growing children and at yearly intervals for all others. epogen promotional code

What should i avoid while taking theophylline

Lithium: Theophylline Derivatives may decrease the serum concentration of Lithium. Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Stopping St. John's Wort may result in theophylline toxicity. buy gynera 5mg uk

What are the possible side effects of theophylline

Case reports of Theophylline overdose in humans and animal studies suggest that phenytoin is ineffective in terminating Theophylline-induced seizures. The doses of benzodiazepines and phenobarbital required to terminate Theophylline-induced seizures are close to the doses that may cause severe respiratory depression or respiratory arrest; the healthcare professional should therefore be prepared to provide assisted ventilation. Elderly patients and patients with COPD may be more susceptible to the respiratory depressant effects of anticonvulsants. Barbiturate-induced coma or administration of general anesthesia may be required to terminate repetitive seizures or status epilepticus. General anesthesia should be used with caution in patients with Theophylline overdose because fluorinated volatile anesthetics may sensitize the myocardium to endogenous catecholamines released by Theophylline. Enflurane appears less likely to be associated with this effect than halothane and may, therefore, be safer. Neuromuscular blocking agents alone should not be used to terminate seizures since they abolish the musculoskeletal manifestations without terminating seizure activity in the brain.

Before taking theophylline

For various North American patient populations from literature reports. In patients with end-stage renal disease, 3-methylxanthine may accumulate to concentrations that approximate the unmetabolized Theophylline concentration. Caffeine concentrations are usually undetectable in adults regardless of renal function. In neonates, caffeine may accumulate to concentrations that approximate the unmetabolized Theophylline concentration and thus, exert a pharmacologic effect. Table IV. Manifestations of theophylline toxicity. Crush one 300 mg extended release tablet in a mortar and reduce to a fine powder.

Monitor the patient and obtain serial theophylline concentrations every 2-4 hours to gauge the effectiveness of therapy and to guide further treatment decisions. Refer to for information regarding table. The average percent fraction of fluctuation was 244%. United States are appropriate, unless specifically indicated otherwise. COPD treatment: Theophylline is currently considered second-line intravenous therapy in the emergency department or hospital setting when there is inadequate or insufficient response to short acting bronchodilators Global Initiative for COPD Guidelines 2013. pantozol

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